Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

orcid logoBjörn Grüning avatar Björn GrüningDevon Ryan avatar Devon RyanFriederike Dündar avatar Friederike Dündarorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoKhaled Jum'ah avatar Khaled Jum'ahVerena Moosmann avatar Verena MoosmannJoachim Wolff avatar Joachim WolffFidel Ramirez avatar Fidel RamirezLeily Rabbani avatar Leily RabbaniNiall Beard avatar Niall Beardorcid logoLucille Delisle avatar Lucille Delisleorcid logoArmin Dadras avatar Armin Dadrasorcid logoHelena Rasche avatar Helena Rascheorcid logoPavankumar Videm avatar Pavankumar Videmorcid logoMartin Čech avatar Martin ČechVivek Bhardwaj avatar Vivek Bhardwajorcid logoMaria Doyle avatar Maria Doyleorcid logoMo Heydarian avatar Mo Heydarianorcid logoMallory Freeberg avatar Mallory Freebergorcid logoNicola Soranzo avatar Nicola Soranzoorcid logoCristóbal Gallardo avatar Cristóbal GallardoGildas Le Corguillé avatar Gildas Le CorguilléMehmet Tekman avatar Mehmet TekmanEkaterina Polkh avatar Ekaterina Polkhorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoAmirhossein Naghsh Nilchi avatar Amirhossein Naghsh Nilchiorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoAnup Kumar avatar Anup KumarMélanie Pétéra avatar Mélanie Pétéraorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoBérénice Batut avatar Bérénice Batutorcid logoFlorian Heyl avatar Florian HeylWilliam Durand avatar William Durandorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoSaskia Hiltemann avatar Saskia HiltemannTorsten Houwaart avatar Torsten Houwaart

Funding

These individuals or organisations provided funding support for the development of this resource

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de.NBI
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Australian BioCommons
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ELIXIR Europe
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The University of Melbourne
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UFR
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Melbourne Bioinformatics
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Collaborative Research Centre 992