Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq epigenetics
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

orcid logoWolfgang Maier avatar Wolfgang Maierorcid logoSaskia Hiltemann avatar Saskia HiltemannMélanie Pétéra avatar Mélanie PétéraMehmet Tekman avatar Mehmet Tekmanorcid logoBérénice Batut avatar Bérénice Batutorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoBjörn Grüning avatar Björn GrüningNiall Beard avatar Niall Beardorcid logoNicola Soranzo avatar Nicola SoranzoVivek Bhardwaj avatar Vivek Bhardwajorcid logoMallory Freeberg avatar Mallory Freebergorcid logoKatarzyna Kamieniecka avatar Katarzyna KamienieckaJoachim Wolff avatar Joachim Wolfforcid logoPavankumar Videm avatar Pavankumar Videmorcid logoArmin Dadras avatar Armin Dadrasorcid logoFlorian Heyl avatar Florian Heylorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoLucille Delisle avatar Lucille DelisleFriederike Dündar avatar Friederike DündarFidel Ramirez avatar Fidel Ramirezorcid logoMaria Doyle avatar Maria Doyleorcid logoAmirhossein Naghsh Nilchi avatar Amirhossein Naghsh Nilchiorcid logoHans-Rudolf Hotz avatar Hans-Rudolf HotzVerena Moosmann avatar Verena MoosmannLeily Rabbani avatar Leily Rabbaniorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoCristóbal Gallardo avatar Cristóbal GallardoGildas Le Corguillé avatar Gildas Le Corguilléorcid logoMartin Čech avatar Martin Čechorcid logoKhaled Jum'ah avatar Khaled Jum'ahEkaterina Polkh avatar Ekaterina Polkhorcid logoMo Heydarian avatar Mo HeydarianWilliam Durand avatar William DurandDevon Ryan avatar Devon Ryanorcid logoHelena Rasche avatar Helena RascheTorsten Houwaart avatar Torsten Houwaartorcid logoAnika Erxleben avatar Anika Erxlebenorcid logoAnup Kumar avatar Anup Kumar

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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Melbourne Bioinformatics
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The University of Melbourne
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Collaborative Research Centre 992
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Australian BioCommons
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ELIXIR Europe
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de.NBI