Epigenetics

DNA methylation is an epigenetic mechanism used by higher eukaryotes and involved in e.g. gene expression, X-Chromosome inactivating, imprinting, and gene silencing of germline specific gene and repetitive elements.

Requirements

Before diving into this topic, we recommend you to have a look at:

Material

You can view the tutorial materials in different languages by clicking the dropdown icon next to the slides () and tutorial () buttons below.
Lesson Slides Hands-on Recordings Input dataset Workflows
Introduction to ChIP-Seq data analysis
Introduction to DNA Methylation data analysis
ATAC-Seq data analysis
CUT&RUN data analysis
DNA Methylation data analysis
Formation of the Super-Structures on the Inactive X
ChIP-seq
Hi-C analysis of Drosophila melanogaster cells using HiCExplorer
Identification of the binding sites of the T-cell acute lymphocytic leukemia protein 1 (TAL1)
ChIP-seq
Infinium Human Methylation BeadChip

Learning Pathways

Or have a look at one of our learning pathways involving this topic. Learning pathways are sets of tutorials curated for you by community experts to form a coherent set of lessons around a topic, building up knowledge as you go. We always recommend to follow the tutorials in the order they are listed in the pathway.
Plot of ChIP-Seq signal from multiple samples across a genome region
Epigenetics data analysis with Galaxy

Familiarize yourself with the Galaxy user interface and its most important features, then move on to analysis of genomic interval and deep-sequencing data with tools and tool suites like MACS2, bedtools and deepTools.

beginner genomic-intervals epigenetics

Frequently Asked Questions

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Editorial Board

This material is reviewed by our Editorial Board:

orcid logoLucille Delisle avatar Lucille Delisleorcid logoFlorian Heyl avatar Florian HeylJoachim Wolff avatar Joachim Wolff

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Contributors

This material was contributed to by:

Vivek Bhardwaj avatar Vivek Bhardwajorcid logoMo Heydarian avatar Mo Heydarianorcid logoMaria Doyle avatar Maria DoyleEkaterina Polkh avatar Ekaterina PolkhFidel Ramirez avatar Fidel Ramirezorcid logoFlorian Heyl avatar Florian HeylVerena Moosmann avatar Verena MoosmannJoachim Wolff avatar Joachim Wolfforcid logoMartin Čech avatar Martin ČechFriederike Dündar avatar Friederike Dündarorcid logoKhaled Jum'ah avatar Khaled Jum'ahLeily Rabbani avatar Leily Rabbaniorcid logoKrzysztof Poterlowicz avatar Krzysztof Poterlowiczorcid logoTristan Reynolds avatar Tristan Reynoldsorcid logoLucille Delisle avatar Lucille Delisleorcid logoArmin Dadras avatar Armin Dadrasorcid logoKatarzyna Kamieniecka avatar Katarzyna Kamienieckaorcid logoCristóbal Gallardo avatar Cristóbal GallardoWilliam Durand avatar William Durandorcid logoPavankumar Videm avatar Pavankumar Videmorcid logoMallory Freeberg avatar Mallory Freebergorcid logoSaskia Hiltemann avatar Saskia Hiltemannorcid logoYvan Le Bras avatar Yvan Le Brasorcid logoWolfgang Maier avatar Wolfgang Maierorcid logoHans-Rudolf Hotz avatar Hans-Rudolf Hotzorcid logoBérénice Batut avatar Bérénice Batutorcid logoBjörn Grüning avatar Björn Grüningorcid logoHelena Rasche avatar Helena RascheMehmet Tekman avatar Mehmet Tekmanorcid logoAnika Erxleben avatar Anika ErxlebenNiall Beard avatar Niall BeardTorsten Houwaart avatar Torsten HouwaartGildas Le Corguillé avatar Gildas Le CorguilléMélanie Petera avatar Mélanie Peteraorcid logoAnup Kumar avatar Anup KumarDevon Ryan avatar Devon Ryanorcid logoNicola Soranzo avatar Nicola Soranzo

Funding

These individuals or organisations provided funding support for the development of this resource

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UFR
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Collaborative Research Centre 992
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Melbourne Bioinformatics
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ELIXIR Europe
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Australian BioCommons
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The University of Melbourne
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de.NBI